- Long-term Survival of a Patient with a Large Hepatocellular Carcinoma with Main Portal Vein Tumor Thrombosis and Spontaneous Tumor Rupture
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Hyung-Woo Lee, Gi-Ae Kim, Chi Hyuk Oh, Jae-Jun Shim, Byung-Ho Kim
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J Liver Cancer. 2020;20(2):148-153. Published online September 30, 2020
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DOI: https://doi.org/10.17998/jlc.20.2.148
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Abstract
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- Optimal treatments for patients with advanced hepatocellular carcinoma (HCC) are still limited and their prognosis remains dismal. Yet, there have been rare cases that have shed light on longer survival in these patients assisted by various treatments. This paper aims to present an extraordinary case of far advanced HCC that had been properly managed in spite of continuous recurrence. A patient visited the hospital with a ruptured large HCC with main portal vein tumor thrombosis but survived longer than 14 years owing to active and prompt interventions.
- Incidence of Primary Liver Cancer in Subjects with Chronic Hepatitis B in Korean National Liver Cancer Screening Program
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In Seung Choi, Chi Hyuck Oh, So Young Park, Sung Eun Ahn, Seong Jin Park, Hyun Rim Choi, Byung-Ho Kim, Jae-Jun Shim
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J Liver Cancer. 2017;17(2):136-143. Published online September 30, 2017
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DOI: https://doi.org/10.17998/jlc.17.2.136
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- Background/Aim
s: To optimize efficacy of National Liver Cancer Screening Program (NLCSP)
for subjects with chronic hepatitis B (CHB), it is needed to know the incidence of liver cancer
and its predisposing factors in the program.
Methods From January 2010 to December 2014, all the hepatitis B surface antigen (HBsAg)
positive participants who received at least two or more abdominal ultrasonography under
NLCSP were retrospectively enrolled in a single tertiary hospital. Annual incidence of primary
liver cancer was calculated and related clinical factors were investigated.
Results During 5 years, 541 subjects were enrolled. Mean age was 53 years old and 292
subjects (54%) were receiving antiviral agents. Liver cirrhosis (LC) was diagnosed in 212 (39.2%).
Mean follow-up time was 2.36 years and 15 hepatocellular carcinoma and 1 intrahepatic
cholangiocarcinoma were diagnosed. Annual incidence of primary liver cancer was 9.8
per 1,000 patient year. Cumulative incidence at 1, 3, and 5 year was 0.6%, 2.6%, and 6.4%,
respectively. In multivariate analyses, LC (hazard ratio [HR] 8.74, 95% confidence interval [CI]
1.97–38.71, P=0.024), age (HR 1.08, 95% CI 1.01–1.15, P=0.024) were significantly associated
with cancer development.
Conclusions Despite of high rate of oral antiviral therapy, incidence of primary liver cancer
is not low in CHB patients in Korea. Old age and presence of LC are independently associated
with higher risk of cancer development during surveillance. This study could be used as
baseline data for quality control of NLCSP.
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Citations
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- Effectiveness of Hepatocellular Carcinoma Surveillance and an Optimal Surveillance Interval: Nationwide Cohort of Korea
Heejin Bae, Sang Ah Lee, Jong Won Choi, Shin Hye Hwang, Sumi Park, Mi-Suk Park Yonsei Medical Journal.2021; 62(8): 758. CrossRef - A Survey of Liver Cancer Specialists’ Views on the National Liver Cancer Screening Program in Korea
Won Sohn, Young-Sun Lee, Jae Geun Lee, Jihyun An, Eun Sun Jang, Dong Ho Lee, Dong Hyun Sinn Journal of Liver Cancer.2020; 20(1): 53. CrossRef - Discrepancy between the Actual Clinical Status of Patients with Hepatocellular Carcinoma and Expectations from Hepatocellular Carcinoma Surveillance: a Single-Center Study
Nak Min Kim, Young Seok Doh, Ji Woong Jang, Seok-Hwan Kim, Hyuk Soo Eun, Jae Hyuck Jun, Sae Hee Kim, Il Hyun Baek, Sung Hee Jung Journal of Liver Cancer.2019; 19(1): 30. CrossRef
- A Case of Hepatocellular Carcinoma Presenting Early Intrahepatic Recurrence Following Hepatic Resection
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Jaejun Shim, Byung-Ho Kim, Young Hwangbo, Sang Wook Lee, Young Ju Lee, Seung Hyung Ha, Jae Young Jang, Seok Ho Dong, Hyo Jong Kim, Young Woon Chang, Rin Chang, Sang Mok Lee
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Journal of the Korean Liver Cancer Study Group. 2009;9(1):33-36. Published online June 30, 2009
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Abstract
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- Long term results of hepatic resection for hepatocellular carcinoma (HCC) are not satisfactory due to a high incidence of
postoperative recurrence. To improve the prognosis in patients who underwent hepatic resection, identification of risk factors
for recurrence and development of effective preventive strategies are required. A single nodular mass was found in the right
hepatic lobe of 53-year old male with B viral cirrhosis by surveillance ultrasonography. Dynamic abdominal CT showed a
3 cm-sized hypervascular mass in the right posteroinferior segment (S6). AFP was 359 ng/mL. Child-Pugh classification was
A, and ICG R15 was 18.8%. After preoperative transarterial chemoembolization (TACE), right hepatic wedge resection was
performed. Resection margin was free of tumor. Microinvasions in the surrounding vessels, lymphatics, bile ducts were not
found and microsatellite nodules were absent in the resected specimen. Although there were no risk factors that associated
with high postoperative recurrence, multifocal intrahepatic recurrence in the right lobe and left medial lobe occurred at 7
months after hepatic resection. He underwent two sessions of TACE.
- A Case of Advanced Hepatocellular Carcinoma Successfully Treated by Repeated Transcatheter Arterial Chemoembolization, Percutaneous Ethanol Injection and Surgical Resection
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Jaejun Shim, Byung-Ho Kim, Jae Young Jang, Seok Ho Dong, Hyo Jong Kim, Young Woon Chang, Rin Chang, Sung Hwa Hong, Joo Hyeong Oh
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Journal of the Korean Liver Cancer Study Group. 2008;8(1):120-123. Published online June 30, 2008
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Abstract
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- Here we report a case of multifocal advanced hapatocellular carcinoma successfully treated by repeated transc
atheter arterial chemoembolization (TACE), percutaneous ethanol injection (PEI) and surgical resection. Previously
healthy 54-year old man was admitted for the evaluation of incidental hepatic masses. Abdominal CT revealed
multifocal hepatic masses in right lobe including segment 5, 6 and 8, which showed early wash-out pattern in
portal phase and increased serum alpha fetoprotein (>840 ng/mL) was compatible with advanced hepatocelluar
carcinoma (stage III). Underlying cirrhosis was noted and Child-Pugh classification was A (5 points). After 4
cycles of TACE, nodular masses in segment 6 and 8 were completely lipiodolized. Viable mass in the remained
huge mass in right anterior lobe was treated by surgical resection. After 4 month operation, abdominal CT
revealed new hepatoma lesion at right anterior lobe, serum AFP was increased to 61 ng/mL. The lesion was
treated by one session of TACE. Underlying chonic hepatitis C was also treated with interferon and ribavirin. The
patient has been followed for 9 years without evidence of regional tumor recurrence or distant metastasis.
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